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Minoxidil (distributed under brand names such as Rogaine™, Regaine™ and RIUP™) is perhaps the best-known treatment for male pattern baldness. Minoxidil is unique because of its topical formulation and availability to both men and women.


Minoxidil was initially used as a treatment for high blood pressure and marketed under the brand name Loniten. After hair growth was discovered as a common side-effect, minoxidil was reformulated by Upjohn Corporation into a 2% topical solution.

In 1988, after clinical trials had concluded, Rogaine became the first treatment approved by the FDA with the indication of treating Androgenetic Alopecia (AGA).

Method of Action

Although minoxidil is the oldest existing medication for AGA, its precise method of action remains unknown. Minoxidil is a potassium channel agonist; meaning that it facilitates in the movement of ions between cells within the body. How this function relates to male-pattern baldness is still being investigated.


Minoxidil is applied twice daily to the scalp, either in foam or liquid form. Customers often report excessive shedding when they start regimens that include Minoxidil. This shedding period is mostly temporary, however, and generally ceases once the body becomes accustomed to the treatment.

Unlike finasteride, minoxidil has the ability to re-grow new hair, albeit in relatively small quantities. It is most effective rejuvenating hairs in the vertex and crown areas of the scalp. Minoxidil has also been found to be quite effective in customers with diffuse thinning.

It should be noted that results will only be seen after 4 months of continuous application. Hairs rejuvenated with minoxidil are generally sparse, weak and often colorless. Once minoxidil treatment is stopped, these minimal gains are lost within a period of 6 months.

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* These statements have not been evaluated by any medical regulatory agencies. These products are not drugs or medicine, and are not intended to diagnose, treat, cure or prevent any disease. The TRX2® products are patent-pending food supplements and patent-pending cosmetic products that help users to maintain normal, healthy hair. Zinc, selenium and biotin contribute to the maintenance of normal hair. Normal hair is also characterised by healthy hair growth and non-excessive hair loss. Results may vary and are subject to your individual metabolism. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using this product. For risks and side-effects, please see the product package insert or info leaflet and consult your physician or healthcare specialist. Read full disclaimer. Read Legal Notices.

Disclaimer: The entire contents of this website are based upon the opinions and research of Oxford Biolabs Ltd., unless otherwise noted. Individual articles are based upon the opinions of the respective author, who may retain copyright as marked. Statements related to the rejuvenation, activation and stimulation of potassium channels are not intended to promote any specific ingredient, regimen, or use and should not be construed as evidence of the safety, effectiveness, or intended uses of the TRX2® products. It is purely presented as information about Oxford Biolabs's research focus and rationality behind formulating the TRX2® food supplement and cosmetics. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Oxford Biolabs Ltd. and its community. Oxford Biolabs Ltd. encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. See our terms of service and privacy policy and full disclaimer here

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