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Ketoconazole is a synthetic anti-fungal drug used to treat a variety of skin conditions including dandruff and athlete’s foot. Although ketoconazole has not been specifically approved for the indication of treating hair loss, it remains an effective adjuvant to existing hair loss regimens. Ketoconazole is distributed by McNeill-PPC, Inc. as a shampoo under the brand name, Nizoral™.

There are several other formulations under which ketoconazole can be administered, including tablets taken orally and creams applied topically. While topical creams have recently been found to have positive effects on hair growth, oral tablets provide no such improvements and can have serious side-effects (especially when combined with other medicines).

History

In 1981, the U.S. Food and Drug Administration (FDA) approved ketoconazole for the treatment of seborrheic dermatitis. A study conducted in 1998 found Nizoral 2% to be just as effective as minoxidil 2% in men affected by androgenetic alopecia (AGA). Nizoral not only increased the number of hairs in the anagen phase of the follicle growth cycle, it also increased the diameter of hair shafts. Because Nizoral has not been specifically approved by the FDA to treat AGA, however, it cannot be marketed as a hair loss product. Nevertheless, many independent experts maintain that Nizoral 1% can significantly improve hair growth.

Method of Action

In addition to having potent anti-fungal properties, ketoconazole works as a 5-alpha-reductase inhibitor and hair growth stimulant. Ketoconazole will not result in the formation of new hair follicles, but it is effective at maintaining and thickening existing hair. When taken orally, ketoconazole can inhibit the production of testosterone within the body. When applied topically, however, this effect is greatly reduced.

Usage

It is recommended that a shampoo product containing ketoconazole (e.g. Nizoral) be used 3-4 times per week. This shampoo should be massaged into the scalp (to remove dead skin cells and increase blood circulation) and left in for 3-5 minutes before being rinsed thoroughly.

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* These statements have not been evaluated by any medical regulatory agencies. These products are not drugs or medicine, and are not intended to diagnose, treat, cure or prevent any disease. The TRX2® products are patent-pending food supplements and patent-pending cosmetic products that help users to maintain normal, healthy hair. Zinc, selenium and biotin contribute to the maintenance of normal hair. Normal hair is also characterised by healthy hair growth and non-excessive hair loss. Results may vary and are subject to your individual metabolism. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using this product. For risks and side-effects, please see the product package insert or info leaflet and consult your physician or healthcare specialist. Read full disclaimer. Read Legal Notices.

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